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pentobarbital will minimize the extent or influence of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Diminished AUC of tramadol along with the Lively metabolite (O-desmethyltramadol) when coadministered with sturdy CYP3A4 and CYP2B6 inducerspentobarbital will reduce the extent or outcome of diazepam b